Back Aesthetic Procedure

Platelet Rich Plasma MyCell® 幹細胞注射

The product

MyCells® is a revolutionary method, based on using ingredients of your own blood, which

can regenerate your skin. These ingredients reside within the fraction of your blood named

"Platelet Rich Plasma" (PRP). PRP is enriched with platelets, stem cells and growth

factors. Once injected into your skin, these substances will accelerate the normal healing

process via new collagen formation at the injected area. This process brings to long lasting

tissue rejuvenation by your own cells. PRP has been widely used for many years in plastic

surgery, orthopedics, dentistry, soft tissue implants, and other types of implants.

10 to 20 minutes prior to treatment, your physician will draw 10 milliliters of your blood,

using a standard procedure, causing minimal pain (like taking a standard blood test).

Thereafter, he will separate the blood into its ingredients, in a procedure that will last 7

minutes. MyCells® is injected below the surface of the skin in the area of fat loss and/or

wrinkles. MyCells® provides a gradual increase in skin thickness. Visible results appear

after the first treatment session.

Treatment results will typically last up to (1-1½) years after the first 3 treatments session in

most patients. Touch-up treatments may be needed to maintain the desired effect.

What is MyCells® Based on?

MyCells® is a method based on using Platelet Rich Plasma (PRP). PRP (Platelet Rich

plasma) is a concentration of human platelets (PLT) in a small volume of plasma. PRP

utilizes the patients own (autologous) PLT, derived from his/her blood.

Why is the excitement about MyCells®?

PRP usage takes advantage of normal the body´s healing pathways, only at an accelerated

rate. During wound healing, many cells rush into the wound site. Among these cells, there

are platelets (PLT).

What do PLT do at the injection site?

• Form blood clots (“PLT gel”).

• Release Growth Factors and proteins (see below).

• Stimulate Stem Cells to regenerate new tissue.

• Accelerate bone healing through Osteo-progenitor cells.

PLT must be intact, in order not to damage these processes!!!

How does MyCells® really work?

• PLT clotting occurs within 10 min after PLT de-granulation, thus anti coagulant in included

within the MyCells® kit.

• The process of releasing growth factors (GF) from platelets is called de-granulation.

During this process, the contents of the PLT -granules are being released by budding from

PLT membranes and addition of side chains. Thus, PLT are requires to be viable and

intact.

• GF bind to Receptors of the cells that are being attracted to the wound.

• Initiation of production of collagen and cell proliferation – Chemo attractant activity –

attract Mesenchymal stem cells to the wound.

• = Acceleration of normal wound healing process.

Growth Factors and proteins released by PLT:

• PDGF:

• Cells replication

Stem cells differentiation

Angiogenesis – vascularisation

Chemo-attraction of Macrophages, fibroblasts

• TGF:

• Induction of connective tissue formation

• ILGF:

• Wound healing

• EGF:

• Induction of cell differentiation

• Fibrin

• Fibronectin

• Vitronectin

MyCells® - Contra-Indications

• Platelet Dysfunction Syndrome

• Critical Thrombocytopenia

• Hypofibrinogenaemia

• Haemodynamic Instability

• Sepsis

• Acute & Chronic Infections

• Chronic Liver Pathology

• Anti-coagulation Therapy

• MyCells®- Lasting Results

According to dozens of injections performed in the UK and Japan, 2-3 consecutive

injections, performed within intervals of 1-3 months, will hold the skin rejuvenation effect for

a minimum period of 12 months, as described in the seen in the scheme below.

Timeline in healing

MyCells® – advantages over competitors:

• MyCells® promotes autologous local tissue growth and repair.

• MyCells® is the only filler that can regenerate wrinkles under the eyes.

• Patient’s safety – MyCells® is made out of patient’s own blood:

• No disease transmission with MyCells®.

• MyCells® is non toxic

• No rejection with MyCells®

• Convenience – MyCells® is prepared at doctor´s office.

• Faster healing – MyCells® accelerates tissue synthesis

• Cost effectiveness – No need for external substances.

• MyCells® is simple and easy to use.

• MyCells® is re-absorbed by the body in a few days.

Certificates

MyCells® harvesting kit - regulatory certificates:

• ISO 13485 - Approved, Nov 2007.

• Israeli Ministry of Health (MOH) – approved, March 2008.

• CE Class II A for in vivo usage (re-injectables) - approved, Feb 2008.

• FDA approval process for in vivo usage - Approval is expected by Q2 2009.